EDU 07 - Challenges and Solutions for Capturing Better Normal Tissue Dose/Volume/Outcome Data to Facilitate its Analyses

Moderator(s)

• 

  Louis Constine, MD, FASTRO, FACR

  University of Rochester
  Rochester, New York, United States
• 

  David Hodgson, MD, FASTRO

  Princess Margaret Cancer Centre
  Toronto, ON, Canada

The safe and effective use of radiation therapy can greatly benefit from tools that will evaluate the anticipated outcomes from competing treatment plans in order to balance NTCPs (normal tissue complication probabilities) with tumor control probabilities. However, our rapidly evolving modern treatment techniques generate highly variable 3D dose distributions, and clinicians often lack evidence-based dose/volume/outcome data to make informed treatment planning decisions. Thus, there is an urgent need for our field to embrace strategies to more accurately and systematically gather such data in a standardized manner. Our technical advances (e.g., with sophisticated RT techniques) must be mirrored by improved workflows and approaches for data capture. Many existing efforts are pediatric-based, perhaps due to the recognition of the critical need to address outcomes of this vulnerable population. We will present several successful and effective pediatric and adult platforms for data acquisition that facilitate analysis of outcomes, including: (1) Childhood Cancer Survivor Study, (2) St. Jude Survivorship Portal, (3) Pediatric Proton and Photon Therapy Comparison Cohort, (4) University of Michigan Learning Health System, and (6)a system developed at the University of Groningen, Netherlands. We will learn about various issues that include: how patients are "enrolled," approaches to grading and scoring input, data access, and reporting and analysis. We will describe the rationale for standardizing our work to facilitate the collection of discrete patient data into an electronic platform, pooling/sharing, and the role that academic journals may/can play in this endeavor.

Presentations:

• 2:45 PM – 2:47 PM ET

  Introductions
  

  Speaker: Louis Constine, MD, FASTRO, FACR – University of Rochester
• 2:47 PM – 2:57 PM ET

  The Importance of Systematic Collection of Data for Radiation Dose and Volume Associations with Late Outcomes in Survivors of Childhood Cancer: The Childhood Cancer Survivor Study
  

  Speaker: Gregory Armstromg, MD, MSCE – St. Jude Children's Research Hospital
• 2:57 PM – 3:07 PM ET

  St. Jude Survivorship Portal: Accessing and Analyzing Comprehensive Data Sets
  

  Speaker: Xin Zhou, PhD – St. Jude Children's Research Hospital
• 3:07 PM – 3:17 PM ET

  University of Michigan Radiation Oncology Analytics Resource (MROAR) System: 9 Years Experience with Standardizations Enabling Automated Aggregation and Analysis from Comprehensive Real-World Data
  

  Speaker: Charles Mayo, PhD, FASTRO, FAAPM – University of Michigan
• 3:17 PM – 3:27 PM ET

  Lessons Learned from the Pediatric Proton/Photon Consortium
  

  Speaker: Torunn Yock, MD, FASTRO, MCH – Massachusetts General Hospital
• 3:27 PM – 3:37 PM ET

  University of Groningen, Netherlands: Prospective Data Registration for NTCP-Model Development and Validation
  

  Speaker: Johannes Langendijk, MD, PhD – University Medical Center Groningen
• 3:37 PM – 3:47 PM ET

  Challenges and Solutions for Capturing Better Normal Tissue Dose/Volume/Outcome Data to Facilitate Its Analyses Perspective/Implications
  

  Speaker: David Hodgson, MD, FASTRO – Princess Margaret Cancer Centre
• 3:47 PM – 4:00 PM ET

  Questions and Answers
  

  Speaker: David Hodgson, MD, FASTRO – Princess Margaret Cancer Centre