EDU 01 - Mechanisms of Non-Apoptotic Cell Death and Implications for Radiation and Immunotherapy

Moderator(s)

• 

  Pippa Cosper, MD, PhD

  University of Wisconsin Madison
  Madison, WI, United States

Over the last 50 years cancer biologists have largely focused on two types of cell death: apoptosis, a programmed and non-inflammatory cell death, and necrosis, an unregulated, inflammatory and immunogenic form of cell death. Other forms of programmed cell death have recently been discovered and represent a caspase-independent "regulated necrosis." These include ferroptosis, pyroptosis and autophagic cell death, among others. Cancer cells can become resistant to certain cell death pathways and activate others under certain stressors. How these alternative cell death pathways are activated or silenced in response to radiation is a nascent area of research. Furthermore, regulated non-apoptotic pathways can be immunogenic, which has significant implications for immunotherapy. It is therefore crucial to gain an understanding of cell death pathways beyond apoptosis as there is great potential for discovery of novel drug and radiosensitizing targets.

Presentations:

• 8:00 AM – 8:02 AM ET

  Introductions
  

  Speaker: Pippa Cosper, MD, PhD – University of Wisconsin Madison
• 8:02 AM – 8:17 AM ET

  Autophagy and Anticancer Immune Responses Driven by Radiotherapy
  

  Speaker: Lorenzo Galluzzi, PhD
• 8:17 AM – 8:32 AM ET

  Inducing Ferroptosis in Lymph Node Cancer Cells to Promote an Immunogenic Response
  

  Speaker: Jessalyn Ubellacker, PhD – Harvard T.H. Chan School of Public Health
• 8:32 AM – 8:47 AM ET

  Molecular Mechanisms of Innate Immune Cell Death and Inflammation in Disease and Therapy
  

  Speaker: Thirumala-Devi Kanneganti, PhD – St. Jude Children's Research Hospital
• 8:47 AM – 9:00 AM ET

  Questions and Answers
  

  Speaker: Pippa Cosper, MD, PhD – University of Wisconsin Madison