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Location: Marriott Marquis
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PQA 02 - PQA 02 Physics Poster Q&A

2318 - Dosimetric Analysis and Outcome Correlations in Intravenous Brachytherapy for Coronary Artery Disease: A Retrospective Study

Sunday, September 29, 2024
4:45 PM – 6:00 PM ET
Location: Hall C

Screen: 20

J. S. Jung1, Y. Cao1, N. Coupey1, L. Huang1, and J. Chang1,2; 1Northwell Health, New Hyde Park, NY, 2Physics and Astronomy, Hofstra University, Hempstead, NY

Purpose/Objective(s): This study analyzes dosimetric parameters for approximately 400 patients treated with intravenous brachytherapy (IVBT) for coronary artery disease at Northwell Health and aims to find a link between radiation treatment and patient outcome. Materials/

Methods: A total of 408 treatments and 366 patients who underwent IVBT for coronary artery disease between 2018 and 2023 were included in the study. The treatment parameters such as lesion size, location, treatment length, treatment dose and source strength, were analyzed. The outcome data were collected from patient follow up records. The negative outcomes were defined as the need for retreatment or cardiac event from the same vessel after one or more IVBT treatments.
Results: Frequency analysis reveals distinct distribution patterns in treatment allocation across different arterial locations. The Right Coronary Artery (RCA) artery emerges as the most frequently treated, accounting for 33% of cases, while the Left Ascending Artery (LAD) and Circumflex artery collectively constitute 46% of treatments. Analysis of the number of patient who returned for retreatment to the same vessel demonstrates that approximately 10% of patients treated with IVBT returned for retreatment within six months of their initial procedure. Out of this 37 patients RCA was retreated the most was at 54% indicating the need for further investigation into treatment effectiveness and recurrence rates for certain vessels.
Conclusion: This retrospective study showed that there were 10% local failures after IVBT treatment. The lack of details of the lesions such as conditions of the vessel wall, the plaque thickness, and property of the existing stent makes it difficult to conclude if dosimetric misses contributed to the outcome. The findings highlight the necessity for ongoing evaluation and refinement of treatment protocols to optimize patient outcomes and minimize the need for repeat interventions. Future research will focus on analyzing patient follow-up data to enhance our understanding of long-term treatment efficacy and patient prognosis in cardiovascular medicine.