3636 - Nasopharynx Cancer in Southeast Asia: An Analysis of 2022 Incidence and Mortality

E. C. Dee¹, M. A. Eala², E. J. G. Feliciano³, L. E. Jacomina⁴, M. L. K. Chua⁵, M. B. Mejia⁶, and N. Y. Lee⁷; ¹Memorial Sloan Kettering Cancer Center, New York, NY, ²Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, ³NYC Health + Hospitals/Elmhurst, New York, NY, ⁴Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, ⁵Department of Head and Neck and Thoracic Cancers, Divisions of Radiation Oncology and Medical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore, ⁶University of Santo Tomas, Benavides Cancer Institute, Manila, Philippines, ⁷Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY

Purpose/Objective(s): Southeast Asia (SEA) is home to 685 million people, that is, almost 9% of the global population. Although the epidemiology of nasopharynx cancer (NPC) is well known in countries like the US and China, less is known about NPC in this large and diverse region. Materials/

Methods: The number of new NPC (C11) cases and deaths were collected from the International Agency for Research on Cancer GLOBOCAN 2022 database for 10 SEA countries by sex and age groups. We report age-standardized incidence and mortality rates (ASIR and ASMR) per 100,000 person-years, and mortality-to-incidence ratio (MIR), a crude measure of survival outcomes.
Results: In 2022 and for men and women combined, NPC was most common in Brunei (ASIR 6.4 per 100,000), Indonesia (ASIR 6.1), and Malaysia (ASIR 5.9), and least common in Cambodia (ASIR 2.1) and Thailand (ASIR 2.2). Of note, ASIR in China was 2.4 per 100,000, and in the US, ASIR was 0.41. With regard to mortality, ASMR was greatest in Indonesia (4.3), Malaysia (4.2), and Brunei (4.1), triple the rates in China (ASMR 1.2) and ~30x the ASMR in the US (0.14 per 100,000). In SEA, ASMR was lowest in Thailand (1.3) and Cambodia (1.5). MIR was greatest in Lao PDR, Cambodia, Malaysia, and Indonesia, and was lowest in Singapore and Thailand. In all SEA countries, ASIR was greater among men than among women. ASMR was also greater among men than among women. ASIR and ASMR are reported per 100,000 population in the table.
Conclusion: In 2022, the incidence of NPC varied greatly within SEA, with ASIR almost three times that of China and over 10x that of the US in countries such as Brunei and Indonesia, highlighting both global and regional heterogeneity. Mortality varied widely as well, with ASMR in Indonesia, Malaysia, and Brunei up to 30x that of the US. Mortality-to-incidence ratio was greatest in lower resourced settings and lowest in Singapore and Thailand, underscoring socioeconomic drivers of survival. Abstract 3636 – Table 1

	Overall ASIR	Overall ASMR	MIR	Male ASIR	Male ASMR	Female ASIR	Female ASMR
Brunei	6.4	4.1	0.64	8.7	5.5	4.0	2.6
Cambodia	2.1	1.5	0.71	3.4	2.7	1.0	0.55
Indonesia	6.1	4.3	0.70	9.6	7.0	2.8	1.7
Lao PDR	3.8	2.9	0.76	5.0	3.9	2.7	2.0
Malaysia	5.9	4.2	0.71	8.9	6.5	2.8	1.8
Myanmar	3.5	2.4	0.69	5.1	3.7	2.1	1.4
Philippines	3.5	2.3	0.66	5.2	3.7	2.1	1.1
Singapore	5.4	2.9	0.54	8.0	4.7	2.7	0.89
Thailand	2.2	1.3	0.59	3.3	2.0	1.2	0.67
Viet Nam	4.7	2.9	0.62	7.1	4.5	2.5	1.5