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PQA 08 - PQA 08 Genitourinary Cancer, Patient Safety, and Nursing/Supportive Care Poster Q&A

3166 - Prostate Cancer in Southeast Asia: An Analysis of 2022 Incidence and Mortality Data

Tuesday, October 1, 2024

2:30 PM – 3:45 PM ET

Location: Hall C

Screen: 9

Presenter(s)

Michelle Ann Eala, MD

UCLA David Geffen School of Medicine/UCLA Medical Center
Los Angeles, CA

M. A. Eala^1,2, E. C. Dee³, L. E. Jacomina⁴, K. Ng⁵, J. M. J. Magsanoc⁶, N. J. Magsanoc⁷, A. V. DAmico⁸, P. L. Nguyen⁸, M. L. Steinberg¹, H. C. Toh⁹, M. L. K. Chua¹⁰, and A. U. Kishan¹; ¹Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, ²College of Medicine, University of the Philippines, Manila, Philippines, ³Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, ⁴Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, ⁵Department of Medical Oncology, University College London Hospitals NHS Foundation Trust, London, United Kingdom, ⁶Department of Radiation Oncology, St. Lukes Medical Center - Global City, Taguig, Philippines, ⁷Division of Urology, Department of Surgery, Philippine General Hospital, Manila, Philippines, ⁸Department of Radiation Oncology, Brigham and Women’s Hospital/Dana-Farber Cancer Institute, Boston, MA, ⁹Division of Medical Oncology, National Cancer Center, Singapore, Singapore, ¹⁰Division of Radiation Oncology, National Cancer Center, Singapore, Singapore

Purpose/Objective(s): The Association of Southeast Asian Nations (ASEAN) is an economic union of 10-member states in Southeast Asia, with a population of 685 million representing over 8% of the global population. Although prostate cancer is known to be one of the most common cancers among men worldwide, a more specific epidemiologic analysis of prostate cancer in Southeast Asia is warranted, given regional heterogeneity in health systems and socio-economic landscapes.

Materials/

Methods: We queried the International Agency for Research on Cancer GLOBOCAN 2022 database for the number of new prostate cancer (C61) cases and deaths by sex and age groups in ASEAN member-states. We present age-standardized incidence and mortality rates (ASIR and ASMR) for prostate cancer per 100,000 person-years, and mortality-to-incidence ratio (MIR), a crude measure of survival outcomes.

Results: In 2022, ASIR of prostate cancer was highest in Singapore (32.8 per 100,000 person-years), Philippines (24.1), and Brunei (21.4), and lowest in Lao PDR (4.1) and Myanmar (4.2). This is in comparison to the US, where ASIR was 75.2. ASMR was highest in the Philippines (10 per 100,000 person-years), Singapore (8.2), and Brunei (5.8), and lowest in Lao PDR (1.9) and Myanmar (2). In the US, ASMR was 8.1. MIR was highest in Myanmar (0.48) and Vietnam (0.47) and lowest in Singapore (0.25) and Brunei (0.27). MIR in the US was 0.11.

Conclusion: Age-standardized incidence and mortality rates for prostate cancer varied greatly among ASEAN member-states in 2022. Incidence was markedly lower than the US, which may in part reflect lower prostate cancer screening rates in the region; however, genetic predisposition and environmental exposures likely play a role as well. Notably, the Philippines had a much higher ASIR and ASMR compared to other lower-middle income ASEAN member-states, signifying the need to bolster prostate cancer care and research in the country. Lower-middle income member-states Lao PDR and Myanmar had low ASIR but relatively higher ASMR (i.e. high MIR), suggesting poorer outcomes among those who are ultimately diagnosed. Determinants of cancer outcomes and their interplay with socio-economics must be explored, including tumor biology, lifestyle, risk factors, as well as health systems and public health interventions.

Abstract 3166 – Table 1

ASEAN Member-State	World Bank Income Level	Overall ASIR	Overall ASMR	MIR
Brunei	High	21.4	5.8	0.27
Cambodia	Lower-middle	5.2	2.4	0.46
Indonesia	Lower-middle	10.5	4.2	0.40
Lao PDR	Lower-middle	4.1	1.9	0.46
Malaysia	Upper-middle	12.9	5.7	0.44
Myanmar	Lower-middle	4.2	2.0	0.48
Philippines	Lower-middle	24.1	10.0	0.41
Singapore	High	32.8	8.2	0.25
Thailand	Upper-middle	12.5	5.5	0.44
Viet Nam	Lower-middle	11.5	5.4	0.47