PQA 01 - PQA 01 Lung Cancer/Thoracic Malignancies and Diversity, Equity and Inclusion in Healthcare Poster Q&A
2072 - Risk of Clinically Significant Cardiovascular Disease Associated with Postoperative Radiotherapy in Non-Small Cell Lung Cancer Patients Receiving Surgical Resection Followed By Adjuvant Chemotherapy:
Seoul National University College of Medicine Seoul, BUS
B. H. Kim1, and J. Kwon2; 1Department of Radiation Oncology, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of (South), 2Department of Radiation Oncology, Chungnam National University Hospital, Daejeon, Korea, Republic of (South)
Purpose/Objective(s): There are no large-scale datasets that analyze the relationship between postoperative radiotherapy (PORT) and various cardiovascular diseases (CVDs) in patients with locally advanced non-small cell lung cancer (NSCLC). Therefore, we aimed to investigate the incidences of CVDs with PORT using a national population-based database. Materials/
Methods: Patients diagnosed with NSCLC who underwent curative surgery followed by adjuvant chemotherapy were included from 2007 to 2017. Patients with a prior diagnosis of heart failure (HF), atrial fibrillation (AFib), or heart surgery were excluded. A total of 11,141 patients were included in the final analysis. PORT was used in 1334 patients. Most patients received lobectomy with mediastinal lymph node dissection. Results: Major adverse cardiac events mostly occurred within 3–4 years from the diagnosis. After the median follow-up duration of 70.6 months, HF was the most diagnosed disease (5.3%), followed by AFib (4.5%), stroke (4.1%), and pulmonary embolism (3.5%). All the incidences of clinically significant CVDs did not differ by PORT. This result remained unchanged after the propensity score matching comparison. Age=65, underlying hypertension, and history of ischemic heart disease were the most related factors to the occurrence of HF and AFib. No significant difference in CVD-free survivals according to PORT status was observed. When stratified by proposed scoring, there were no subgroups showed increased incidence by PORT. Conclusion: These results suggest that PORT had no significant impact on various CVD occurrences in NSCLC patients without underlying heart disease.
