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Location: Marriott Marquis
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PQA 05 - PQA 05: Breast Cancer and Nonmalignant Disease Poster Q&A

2728 - Impact of Strength Training on Metabolism, Body Composition, Strength and Mobility during Adjuvant Radiotherapy for Breast Cancer

Monday, September 30, 2024
3:00 PM – 4:00 PM ET
Location: Hall C

Screen: 16

P. Shamsesfandabadi1, F. Sourial1, M. Shams Esfand Abadi2, Y. Yin3, C. Peluso4, S. Beriwal1, and C. E. Champ1; 1Allegheny Health Network Cancer Institute, Department of Radiation Oncology, Pittsburgh, PA, 2Department of Mathematical Science, University of Nevada, Las Vegas, Las Vegas, NV, 3Allegheny Health Network, Pittsburgh, PA, 4Exercise Oncology and Resiliency Center, Allegheny Health Network, Pittsburgh, PA

Purpose/Objective(s): Obesity increases breast cancer(BC) risk, exacerbated by weight gain during and after treatment (Tx), while higher activity levels are associated with a decrease in incidence and improvement in outcomes. We analyzed metabolic, body composition, strength, and mobility metrics from 3 IRB approved prospective cohorts at our Exercise Oncology Center (EOC) undergoing an exercise intervention during BC Tx with radiation therapy (RT): EXERT-BC, EXERT-C, and EXERT-BCN Materials/

Methods: An intensive exercise regimen 3 per week for 3 months featuring compound movements with linear progression to enhance strength and mobility is done. Body composition was measured with bioimpedance analysis (BIA) (InBody 990) and ultrasound performing the Jackson & Pollack calculation (BodyMetrix). Mobility and balance were assessed through functional movement screening (FMS) and the Y-balance test and activity was assessed via Godin Questionnaires

Results: For 86 participants with average age of 56.5 yo, RT was planned as partial for 29.1%, WBRT for 30.2%, WBRT+RNI for 40.7%. 60 (69.8%) women began the program during RT, 26 (30.2%) started after RT completed. 62 (73.8%) underwent SLNB, 11 (13.1%) had ALND. Lumpectomy for 58 (67.4%) and mastectomy for 23 (26.7%). As highlighted in table 1, body fat (lb and %) on BIA and US significantly decreased while muscle mass (lb and %), fat free mass, RMR, Godin, FMS, and balance for both sides exhibited significant improvement following the exercise. After the program whole body phase angle, grip strength of both arms (measured at overhead and waist positions) showed significantly higher mean values

Conclusion: A structured and intense weight training program is both safe and effective for improvement in body composition, strength, and mobility during adjuvant RT in BC. To our knowledge, this is a largest reported cohort engaging in intense weight training during RT to help making prescribed exercise part of the SOC during BC Tx.

Abstract 2728 – Table 1

Baseline After exercise P
Wt lb 170.25(142.0-200.1) 166.40(142.0-195.7) .0007
InBody BF lb 68.05(47.6-87.8) 61.52(43.4-89.0) <.0001
InBody BF % 38.4(33.4-44.1) 37.05(30.8-43.5) <.0001
US BF % 35.33 32.07 <.0001
US Essential BF lb 55.1(44.2-63.5) 54.6(39.1-66.0) .0475
US Excess BF % 4.1(0-17.9) 0(0-8.0) <.0001
InBody MM lb 55.9(51.6-61.5) 57.3(52.0-62.4) <.0001
InBody MM % 33.41(30.50-35.87) 35.40(31.54-38.92) <.0001
InBody FFM lb 102.05(95.7-111.6) 105.05(95.9-113.3) <.0001
US FFM % 29.4(26.3-31.8) 30.0(27.5-33.4) <.0001
InBody RMR kcal/m 1388(1316-1461) 1399.5(1309-1480) <.0001
US RMR kcal/m 1436.5(1329-1525) 1461(1353-1583) <.0001
BMC g 6.23(5.67-6.77) 6.26(5.69-6.79) .2266
Whole Body Angle degrees 4.95 5.15 <.0001
Godin 21.5(9-36) 43(36-56) <.0001
FMS 10(8-11) 14(10-17) <.0001
Grip, R overhead 20.92 24.32 <.0001
Grip, R waist 23.4 25.97 <.0001
Grip, L overhead 21.4 25.17 <.0001
Grip, L waist 22.75 26.28 <.0001
Y-BT, L 72.65(63.8-82.2) 81.1(66.3-89.25) .0127
Y-BT, R 74.2(63.12-83.3) 85.74(76.52-95.4) <.0001