EDU 47 - Intersection of Immuno-Molecular-Genetic Profiling and Implications for Immunotherapy (IT) and Immunotherapy-Radiotherapy (IT-RT) Combinations
Biologically-Guided Approaches to Address Intrinsic Resistance to IT-RT Combinations
University of Pittsburgh, UPMC Hillman Cancer Center Pittsburgh, PA
Learning Objectives:
Explain the intersection/interplay between tumor-intrinsic genetics/epigenetics and anti-tumor immunity and discuss the implications for response to immunotherapy.
Describe the landscape of molecular-genetic tumor profiling and NGS assays and how this information is currently integrated into clinical practice.
Identify potential strategies to implement biologically-guided, immuno-molecular-genomic profiling to more carefully select patients likely to benefit from IT-RT combinations.