PRO 07 - Gynecologic Tumor Board - Case-Based Discussion of the Molecular and Treatment Approach Updates for the Management of Endometrial, Vulvar and Cervical Cancers

Moderator(s)

• 

  Elizabeth Kidd, MD

  Stanford University
  Stanford, CA, United States
• 

  Malolan Rajagopalan, MD, MBA

  Mount Carmel Health System
  Grove City, OH

Using a multidisciplinary case-based approach, this session will discuss recent studies important for the management of gynecologic cancer. The session will include a gynecologic pathologist for review and discussion of the significance of recent additions to gynecologic pathology reports that are becoming more common, including the four molecular groups and extent of lymphovascular invasion (LVI) for endometrial cancer, HPV status for vulvar cancer, and PD-L1 expression for cervical cancer. The endometrial case discussion will highlight the updates in FIGO staging with the inclusion of molecular status and LVI, emerging data suggesting molecular status should influence treatment approach for endometrial cancers and role of immunotherapy for advanced stage disease. The vulvar and cervical cancer case discussions will highlight how to use pathologic features, such as HPV status and PD-L1 expression to help guide treatment approach. Additionally, how to interpret recently reported contrasting data, in particular for immunotherapy and neoadjuvant chemotherapy, for locally advanced cervical cancer will be reviewed to help optimize patient selection for these new treatment approaches for definitive management.

Presentations:

• 5:00 PM – 5:02 PM ET

  Introductions
  

  Speaker: Elizabeth Kidd, MD – Stanford University
• 5:02 PM – 5:22 PM ET

  Gynecologic Molecular Pathology Review for Endometrial, Vulvar and Cervix Cancers
  

  Speaker: Taylor Jenkins, MD – Virginia Commonwealth University
• 5:22 PM – 5:42 PM ET

  Endometrial Cancer Staging and Treatment Updates - The Significance of Pathology and Molecular Status
  

  Speaker: Susan Gueble, MD, PhD – Yale University School of Medicine
• 5:42 PM – 6:02 PM ET

  Vulvar and Cervical Cancer Treatment Updates
  

  Speaker: Junzo Chino, MD, FASTRO – Duke Cancer Institute
• 6:02 PM – 6:15 PM ET

  Questions and Answers
  

  Speaker: Malolan Rajagopalan, MD, MBA – Mount Carmel Health System