Radiation and Cancer Biology
AMA PRA Category 1 Credits 1.00
CAMPEP Credits: 1.00
MDCB Credits: 1.00
James Yu, MD, FASTRO, MHS
Connecticut Radiation Oncology, PC
Hartford, CT, United States
Tumor phylogenetics (or cancer phylogenetics) is the scientific method used to consider cancer biology through the lens of computational evolutionary biology. This method, also known as phylogenetic tree inference, attempts to understand how genetic changes in primary and secondary tumors evolve over time and in response to cancer therapy and environmental stress. This session will be in three parts and will be targeted to interested clinicians and radiation biologists. The first speaker, Dr. J. Nick Fisk, will describe the basics of phylogenetic algorithms and the current state of knowledge, drawing on their work with EGFR driven lung cancer and the characterization of small renal masses. The second speaker, Dr. Jacob Scott, will discuss the concept of collateral sensitivity and its implications for the combination of radiation and systemic therapy. Finally, Dr. James Yu will discuss the theoretical implications of this work for oligometastatic disease. This proposal has been generated by ASTRO Science Education and Program Development (SEPD) Committee members and reflects the inclusion of scientific content and new scientific advances in the field.
Speaker: James Yu, MD, FASTRO, MHS – Connecticut Radiation Oncology, PC
Speaker: Jacob Scott, MD, PhD – Cleveland Clinic Taussig Cancer Center
Speaker: James Yu, MD, FASTRO, MHS – Connecticut Radiation Oncology, PC
Speaker: Nic Fisk, PhD – University of Rhode Island
Speaker: James Yu, MD, FASTRO, MHS – Connecticut Radiation Oncology, PC